Thermo Fisher Scientific Foxp3 Polyclonal Antibody

Thermo Fisher Scientific Foxp3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• This affinity purified antibody is directed against mouse Foxp3.
• BLAST analysis indicates cross-reactivity with mouse, human, and Macaca fascicularis based on 100% sequence homology.

Target Information

FOXP3 (Forkhead box protein 3) is a transcriptional regulator of the forkhead/winged-helix family, conserved across mammals and essential for immune homeostasis.
It is expressed at high levels in CD25+ CD4+ regulatory T cells, lower levels in CD4+/CD25− cells, and absent in CD4−/CD8+ T cells.
FOXP3 acts as a master regulatory gene and marker of regulatory T cells.
Defects in FOXP3 cause the scurfy phenotype in mice and IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome) in humans.
In human breast and colon cancer cells, FOXP3 expression is regulated by p53 in response to DNA damage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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