Thermo Fisher Scientific HRAS Monoclonal Antibody (OTI1G8), TrueMAB

Applications

• Luminex (LUM): Assay-dependent

Product Specifications

Target Information

Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to numerous downstream signaling pathways leading to distinct cytoplasmic or nuclear events. Each mammalian cell contains three Ras proto-oncogenes coding for closely related Ras proteins: H-, K-, and N-Ras. Oncogenic mutations in Ras genes are present in approximately 30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression stimulates proliferation and inhibits apoptosis.
K-Ras mutations are common in pancreatic, colorectal, and non-small-cell lung carcinomas; H-Ras mutations are common in bladder, kidney, and thyroid carcinomas; N-Ras mutations are found in melanoma, hematological malignancies, and hepatocellular carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.