Thermo Fisher Scientific HRAS Monoclonal Antibody (OTI1G8), TrueMAB
HRAS 단백질을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. TrueMAB 형식의 고순도 항체이며 Luminex 등 다양한 면역 분석에 사용 가능합니다. Affinity chromatography로 정제되었으며 PBS 버퍼에 보관됩니다.
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Applications
- Luminex (LUM): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G8 |
| Immunogen | Full length human recombinant protein of HRAS produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with <5% trehalose |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to numerous downstream signaling pathways leading to distinct cytoplasmic or nuclear events. Each mammalian cell contains three Ras proto-oncogenes coding for closely related Ras proteins: H-, K-, and N-Ras. Oncogenic mutations in Ras genes are present in approximately 30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression stimulates proliferation and inhibits apoptosis.
K-Ras mutations are common in pancreatic, colorectal, and non-small-cell lung carcinomas; H-Ras mutations are common in bladder, kidney, and thyroid carcinomas; N-Ras mutations are found in melanoma, hematological malignancies, and hepatocellular carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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