Thermo Fisher Scientific FAM89B Polyclonal Antibody
Thermo Fisher Scientific의 FAM89B Polyclonal Antibody는 인간 FAM89B 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot과 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며, TGF-beta 신호 조절 관련 연구에 활용 가능합니다.
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Thermo Fisher Scientific FAM89B Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FAM89B. Recombinant protein control fragment (Product #RP-100459). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Lot-Specific |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641479 |
Product Specific Information
- Immunogen sequence: RKEMLWGLYE SIQDYKHLCQ DLSFCQDLSS SLHSDSSYPP DAGLS
- Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 89%
Target Information
FAM89B negatively regulates TGF-beta-induced signaling; in cooperation with SKI, it prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter mediating specific recognition of LIMK1 by CDC42BPA and CDC42BPB in lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and subsequent phosphorylation of CFL1, which is important for lamellipodial F-actin regulation. [UniProt]
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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