Thermo Fisher Scientific SETD2 Monoclonal Antibody (OTI1B4), TrueMAB
SETD2 단백질을 인식하는 Mouse 모노클로날 항체로, Western blot에 최적화됨. 인간 유래 단백질 조각(aa 1787–2144)을 면역원으로 사용. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol 완충액에 보관. -20°C에서 보관하며 동결-해동 반복은 피해야 함.
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Applications
- Western Blot (WB): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1787–2144 of human SETD2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Histone methyltransferase that specifically trimethylates Lys-36 of histone H3 (H3K36me3) using dimethylated Lys-36 (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state by recruiting DNA methyltransferase DNMT3A. Enhanced in intron-containing genes, suggesting coupling between splicing and elongating RNA polymerase recruitment. Required during angiogenesis and recruited to adenovirus 12 E1A gene promoters upon infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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