Thermo Fisher Scientific MTDH Monoclonal Antibody (OTI2A6), TrueMAB
Human MTDH 단백질(aa 70-582)을 항원으로 제작된 Mouse monoclonal antibody로 Western blot에 적합. Affinity chromatography로 정제된 1 mg/mL 액상 제품이며, PBS/BSA/glycerol buffer에 보관. Metadherin 단백질 연구용으로 사용.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 70–582 of human MTDH produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC (Lysine-Rich CEACAM1 co-isolated), localizes with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It functions as a regulatory component during tight junction maturation rather than as a structural element. Metadherin is overexpressed in breast cancer tissues and xenografts, with lower expression in normal breast tissue. It binds lung vasculature via a C-terminal extracellular domain segment, and inhibition of this interaction has been reported to suppress breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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