Thermo Fisher Scientific Phospho-ATF2 (Ser112, Ser94) Polyclonal Antibody
ATF2 단백질의 Ser112 및 Ser94 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 고순도 정제 및 안정한 PBS/glycerol 저장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ATF2 (Accession P15336), corresponding to amino acid residues around phosphorylated Ser112. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816276 |
Product Specific Information
This antibody detects endogenous levels of ATF2 only when phosphorylated at Serine 112 or Serine 94.
Target Information
ATF-2 (also known as CRE-BP1) is a transcription factor that binds to AP-1 and CRE DNA response elements and belongs to the ATF/CREB family of leucine zipper proteins. It interacts with viral oncoproteins and cellular tumor suppressors and is a target of SAPK/JNK and p38 MAP kinase signaling pathways. Cellular stress such as genotoxic agents, inflammatory cytokines, and UV irradiation activate ATF-2 transcriptional activity via phosphorylation at Thr69 and Thr71. Both SAPK and p38 MAPK phosphorylate ATF-2 at these sites in vitro and in transfected cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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