Thermo Fisher Scientific CCBE1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The gene encoding CCBE1 (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18, a region often deleted in breast and prostate cancers.
CCBE1 is a 406 amino acid secreted protein containing two collagen-like domains and one calcium-binding EGF-like domain.
EGF-like domains typically include six cysteine residues forming disulfide bonds, and calcium-binding EGF-like domains can be affected by amino acid substitutions that disrupt structure or calcium affinity, altering protein function.
Downregulation of CCBE1 is frequently observed in breast cancer, suggesting that loss of CCBE1 affects cell adhesion and mobility due to its extracellular nature.
Three isoforms of CCBE1 are produced by alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.