Thermo Fisher Scientific CCBE1 Polyclonal Antibody
CCBE1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합하며, Human, Mouse, Rat 시료에 반응합니다. Protein A로 정제된 액상 형태로, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human CCBE1 (amino acids 201–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The gene encoding CCBE1 (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18, a region often deleted in breast and prostate cancers.
CCBE1 is a 406 amino acid secreted protein containing two collagen-like domains and one calcium-binding EGF-like domain.
EGF-like domains typically include six cysteine residues forming disulfide bonds, and calcium-binding EGF-like domains can be affected by amino acid substitutions that disrupt structure or calcium affinity, altering protein function.
Downregulation of CCBE1 is frequently observed in breast cancer, suggesting that loss of CCBE1 affects cell adhesion and mobility due to its extracellular nature.
Three isoforms of CCBE1 are produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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