Thermo Fisher Scientific Oncomine TCR Beta-LR Assay GX

Thermo Fisher Scientific Oncomine™ TCR Beta-LR Assay GX

The Oncomine TCR Beta-LR Assay GX is designed to measure T cell diversity and clonal expansion by sequencing T-cell receptor beta chain rearrangements.
This assay kit provides single-pool multiplex panel library reagents to perform up to 32 sequencing reactions.
Optimized for long-read sequencing on the Ion Torrent Genexus Integrated Sequencer using the Ion Torrent Genexus GX5 Chip, it enables automated library preparation, sequencing, analysis, and reporting—all within a single day workflow.

주요 특징

• Long-read RNA sequencing covering the TCR beta chain
• Detection of clones over a wide dynamic range
• Efficient workflow with 24-hour sample-to-result time
• Flexible RNA input (10 ng to 1 μg)
• Compatible with fresh-frozen tissue, whole blood, and sorted cells
• Streamlined informatics solution with multi-sample analysis functionality

연구 응용 분야

• Characterization of T lymphocyte diversity in blood and tumor tissue
• Identification of variable gene polymorphisms related to autoimmune or immune-mediated diseases
• Optimization of therapeutic or engineered T cell manufacturing and function

기술 개요

The assay captures all three complementarity-determining regions (CDR1, CDR2, CDR3) of the TCR beta chain with high accuracy.
Using RNA templates allows sequencing of productive and relevant V(D)J rearrangements, enabling identification of rare and abundant clones.

사양

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