Thermo Fisher Scientific FOLH1 Monoclonal Antibody (UMAB25), UltraMAB

Applications and Tested Dilution

Product Specifications

Target Information

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-L-aspartyl-L-glutamate. It is expressed in tissues such as the prostate, central and peripheral nervous system, and kidney. Mutations in this gene may lead to impaired intestinal absorption of dietary folates, resulting in low blood folate and hyperhomocysteinemia. Expression in the brain may be associated with pathological conditions linked to glutamate excitotoxicity. In the prostate, the protein is up-regulated in cancerous cells and serves as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region, and alternative splicing gives rise to multiple transcript variants encoding several isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.