Thermo Fisher Scientific PIEZO1 Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
SVVGVVNQPI DVTVTLKLGG YEPLFTMSAQ QPSIIPFTAQ AYEELSRQFD PQPLAMQFIS QYSPEDIVTA QIEGSSGALW RISPPSRAQM KRELYNGTAD ITLRFTWNFQ RDLAKGGTVE YANEKH

Sequence identity:

• Mouse: 95%
• Rat: 93%

Target Information

Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel, generating currents with a linear current-voltage relationship sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer.

Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER and subsequent stimulation of calpain signaling. In the kidney, Piezo1 may contribute to detection of intraluminal pressure changes and urine flow sensing.

Piezo1 acts as a shear-stress sensor that promotes endothelial cell organization and alignment in blood flow direction via calpain activation, essential for vascular formation and structure in both development and adult physiology.

The protein encoded by the Piezo1 gene is a mechanically activated ion channel linking mechanical forces to biological signals. Mutations in this gene are associated with dehydrated hereditary stomatocytosis and lymphedema.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.