Thermo Fisher Scientific PIEZO1 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PIEZO1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PIEZO1,uniProtId:Q92508-1,ncbiNodeId:9606,antigenRange:2199-2324,antigenLength:2521,antigenImageFileName:PA5-61460_PIEZO1_Q92508-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61460_PIEZO1_Q92508-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645537

Product Specific Information

Immunogen sequence: SVVGVVNQPI DVTVTLKLGG YEPLFTMSAQ QPSIIPFTAQ AYEELSRQFD PQPLAMQFIS QYSPEDIVTA QIEGSSGALW RISPPSRAQM KRELYNGTAD ITLRFTWNFQ RDLAKGGTVE YANEKH

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 93%.

Target Information

Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel, and generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer. Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, Piezo1 may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Piezo1 acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation and plays a key role in blood vessel formation and vascular structure in both development and adult physiology. The protein encoded by the Piezo1 gene is a mechanically-activated ion channel that links mechanical forces to biological signals. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. Diseases associated with PIEZO1 include Dehydrated Hereditary Stomatocytosis with/without Pseudohyperkalemia And/Or Perinatal Edema and Lymphedema.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.