Thermo Fisher Scientific GPNMB Monoclonal Antibody (OTI2H7), TrueMAB
인간 GPNMB 단백질(aa 508-572)에 특이적인 마우스 단클론 항체. Western blot에 최적화되어 있으며, 동결건조 형태로 제공. PBS 완충액(8% 트레할로스) 내 보존, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 508–572 of human GPNMB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The protein encoded by this gene is a type I transmembrane glycoprotein homologous to the pMEL17 precursor, a melanocyte-specific protein.
GPNMB is expressed in lowly metastatic human melanoma cell lines and xenografts, but not in highly metastatic lines.
It may play a role in growth delay and reduction of metastatic potential.
Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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