Thermo Fisher Scientific PLC gamma2 Polyclonal Antibody
PLC gamma2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. WB 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, 안정적인 PBS 버퍼에 보존. 연구용으로 세포 신호전달 분석에 적합.
- 카탈로그번호
- 500-12474
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide of human PLC gamma 2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Jurkat whole cell lysate
- Cellular location: Cell projection, lamellipodium, ruffle. Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction through the generation of two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.
Mammalian PLC isozymes include PLC beta1, beta2, beta3, beta4, gamma1, gamma2, delta1, delta2, and PLCε.
PLC delta exists as four isoforms. PLC delta1 acts as a calcium signal amplifier and is activated by an atypical GTP-binding protein. It functions as an effector for transglutaminase II-mediated oxytocin receptor and alpha1B-adrenoreceptor signaling.
Mouse PLC delta1 is highly expressed in brain, heart, lung, and testis. Abnormal accumulation of PLC delta in Alzheimer’s disease brains suggests its involvement in AD pathology. PLC delta2 is markedly expressed in type II intestinal metaplasia and adenocarcinoma, and may serve as a marker of gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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