Thermo Fisher Scientific NCOA2 Polyclonal Antibody
NCOA2 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. 고순도 Protein A 정제, 액상 형태, 안정적인 저장 조건 제공.
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Thermo Fisher Scientific NCOA2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human NCOA2/KAT13C, amino acids 701–800 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator 2, NCOA2 or TIF2, aids in the function of nuclear hormone receptors. These receptors act as conditional transcription factors, regulating genes involved in cell growth, development, and homeostasis. Members of the nuclear hormone receptor superfamily possess three domains:
- N-terminal transcriptional activation domain
- Central DNA-binding domain
- C-terminal hormone-binding domain
Before hormone binding, steroid receptors remain inactive in a complex with heat-shock protein-90 and other stress-related proteins. Upon hormone binding, they undergo conformational changes, dissociate from inhibitory complexes, bind DNA enhancer elements as homodimers, and modulate transcription. Transcriptional coactivator proteins such as SRC2 are essential for initiating transcription after receptor binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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