Thermo Fisher Scientific p21 Monoclonal Antibody (HJ21)
Cyclin-dependent kinase 억제 단백질 p21을 인식하는 Mouse monoclonal antibody (Clone HJ21). Western blot, IHC, ICC 등 다양한 응용 가능. Human 및 Mouse 시료에서 검증됨. 비결합형 액상 형태로 4°C 보관.
- 카탈로그번호
- AHZ0422
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific p21 Monoclonal Antibody (HJ21)
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 8 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | Assay-dependent | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HJ21 |
| Immunogen | Human recombinant p21WAF1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536378 |
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. It plays a key role in the cellular response to genotoxic stress and is a major transcriptional target of the p53 protein. Nuclear p21 binds and inhibits CDK1 and CDK2, preventing cell cycle progression from G1 to S phase or G2 to mitosis after DNA damage, allowing DNA repair. In the cytoplasm, p21 has anti-apoptotic effects by inhibiting caspase 3 and apoptotic kinases ASK1 and JNK. Thus, p21 exhibits dual functions in carcinogenesis, acting both as a tumor suppressor and as an oncogene depending on context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.