Thermo Fisher Scientific p21 Monoclonal Antibody (HJ21)
Cyclin-dependent kinase 억제 단백질 p21을 인식하는 Mouse monoclonal antibody (Clone HJ21). Western blot, IHC, ICC 등 다양한 응용 가능. Human 및 Mouse 시료에서 검증됨. 비결합형 액상 형태로 4°C 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 8 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | Assay-dependent | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HJ21 |
| Immunogen | Human recombinant p21WAF1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536378 |
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. It plays a key role in the cellular response to genotoxic stress and is a major transcriptional target of the p53 protein. Nuclear p21 binds and inhibits CDK1 and CDK2, preventing cell cycle progression from G1 to S phase or G2 to mitosis after DNA damage, allowing DNA repair. In the cytoplasm, p21 has anti-apoptotic effects by inhibiting caspase 3 and apoptotic kinases ASK1 and JNK. Thus, p21 exhibits dual functions in carcinogenesis, acting both as a tumor suppressor and as an oncogene depending on context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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