Thermo Fisher Scientific BUBR1 Monoclonal Antibody (8G1), HRP
Thermo Fisher Scientific의 BUBR1 Monoclonal Antibody (8G1), HRP는 인간 및 생쥐 시료에 반응하며 Western blot에 최적화된 HRP 결합 항체입니다. 단일클론(Mouse IgG1, kappa)으로 높은 특이성과 재현성을 제공하며, 4°C 암소 보관이 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8G1 |
| Immunogen | A portion of hBUBR1 tagged at the N-terminus with pMAL (residues 1–350 of human BUBR1) |
| Conjugate | HRP |
| Form | Liquid |
| Concentration | 0.74 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_11151954 |
Additional Formats
Product Specific Information
This antibody should not cross-react with hBUB1.
Target Information
BUBR1 is a member of the Ser/Thr protein kinase family and a key component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. Defective spindle checkpoints can lead to genetic instability and promote malignant transformation.
Human cells express two related checkpoint kinases derived from the BUB1 gene: hBUBR1 and hBUB1. Both monitor kinetochore-microtubule interactions during mitosis.
hBUBR1 is essential for normal mitotic progression, preventing premature entry into anaphase. It has been detected in various human cancers and identified as a binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which may accelerate breast cancer progression by compromising checkpoint control through BUBR1 inactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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