Thermo Fisher Scientific BUBR1 Monoclonal Antibody (8G1), HRP

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:5,000

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• Request custom conjugation

Product Specific Information

This antibody should not cross-react with hBUB1.

Target Information

BUBR1 is a member of the Ser/Thr protein kinase family and a key component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. Defective spindle checkpoints can lead to genetic instability and promote malignant transformation.
Human cells express two related checkpoint kinases derived from the BUB1 gene: hBUBR1 and hBUB1. Both monitor kinetochore-microtubule interactions during mitosis.
hBUBR1 is essential for normal mitotic progression, preventing premature entry into anaphase. It has been detected in various human cancers and identified as a binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which may accelerate breast cancer progression by compromising checkpoint control through BUBR1 inactivation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.