Thermo Fisher Scientific TrkB Polyclonal Antibody
Thermo Fisher Scientific의 TrkB Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 rabbit polyclonal 항체입니다. Western blot 및 IHC(P) 분석에 적합하며, TrkB 단백질 특이적 인식이 가능합니다. 연구용으로 신경계 발달 및 BDNF 관련 신호 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human TrkB conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity: TrkB.
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides crucial for development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway, leading to cell differentiation.
Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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