Thermo Fisher Scientific TrkB Polyclonal Antibody
TrkB 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간, 마우스, 랫트 시료에 반응합니다. Western Blot과 Immunohistochemistry에 사용 가능하며, 신경계 발달 및 유지 연구에 적합합니다. Lyophilized 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
- 카탈로그번호
- OST00128G-500UG
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific TrkB Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous (PubMed) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human TrkB conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: TrkB.
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family of polypeptides essential for mammalian nervous system development and maintenance. NTRK2 acts as the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway, leading to cell differentiation. TrkB expression is confined to central and peripheral nervous system tissues. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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