Thermo Fisher Scientific TAB182 Polyclonal Antibody
TAB182 단백질을 인식하는 염소 유래 polyclonal 항체로, IHC(P)에서 5 µg/mL 농도로 사용 가능. 인간 시료에 반응하며, 비결합(Unconjugated) 상태로 제공. 0.5 mg/mL 농도의 액상 형태로, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence KVSTLRESSAMAS-C (aa 2–14) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932684 |
Product Specific Information
- Tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
- Preliminary analysis showed no signal in Western Blot.
Target Information
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins.
Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 inhibits its binding and induces telomere elongation.
TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain, suggesting that TAB182 may act as a scaffold mediating higher-order protein complex formation at telomeres.
TAB182 has also been suggested to serve a role in the cytoplasm, localizing to the cytoplasmic cortical actin network.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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