Thermo Fisher Scientific DMAP1 Recombinant Rabbit Monoclonal Antibody (23GB5680)
Recombinant rabbit monoclonal antibody targeting human DMAP1 (clone 23GB5680). Validated for Western blot and flow cytometry. High purity via affinity chromatography, supplied in PBS with glycerol. Suitable for research on transcriptional regulation an...
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Flow Cytometry (Flow)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB5680 |
| Immunogen | A synthesized peptide derived from human DMAP1 (411–467AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
DNA methyltransferase 1-associated protein 1 (DMAP1) is involved in the repression or activation of transcription. It can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 joins this complex to deacetylate histones in transcriptionally inactive heterochromatin following replication.
DMAP1 also potentiates DAXX-mediated repression of glucocorticoid receptor-dependent transcription. It is a component of the nucleosome acetyltransferase of H4 complex and interacts with transcriptional corepressor tumor susceptibility gene 101 and pro-apoptotic death-associated protein 6. DMAP1 is conserved across species from yeast to humans. The human DMAP1 gene is localized on chromosome 1p34.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: MA5-53098_DMAP1_Q9NPF5-1_Rabbit.svg, MA5-53098_DMAP1_Q9NPF5-1_Rabbit_PDP.jpeg)
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