Thermo Fisher Scientific MLK4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MLK4. Validated for Western blot and immunoprecipitation. Supplied as liquid, unconjugated form at 0.2 mg/mL. Recommended storage at 4°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 986 and 1036 of human mixed lineage kinase 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
MLK4 (mixed lineage kinase 4) belongs to the superfamily of MAP kinase kinases (MAP3K1), containing both serine/threonine and tyrosine kinase activity in their catalytic domains. The structure of this kinase family includes an N-terminal Src homology (SH3) domain, a kinase domain, a leucine zipper region, and a CDC42/RAC-interactive binding (CRIB) motif, with divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas. It acts as a negative regulator of TLR4 and does not activate JNK1/MAPK8, p38/MAPK14, or ERK2/MAPK1 pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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