Thermo Fisher Scientific c-myc Polyclonal Antibody, Agarose

Applications

Tested Dilution

Publications

Immunoprecipitation (IP)

0.1-1mg

-

Product Specifications

Species Reactivity

Tag

Host/Isotype

Goat

Class

Polyclonal

Type

Antibody

Immunogen

Amino acids 410-419 (EQKLISEEDL) of human myc conjugated to KLH.

Conjugate

Agarose Agarose Agarose

Form

Liquid

Concentration

0.5-1.0 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

2-8°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Myc is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.