Thermo Fisher Scientific CYP3A4 Polyclonal Antibody
Rabbit polyclonal antibody against CYP3A4 for detection in human, mouse, and rat samples. Validated for Western blot applications. Affinity purified with high specificity. Supplied in liquid form with 1.03 mg/mL concentration. For research use only.
- 카탈로그번호
- PA528323
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 101–381 of Human CYP3A4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.03 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545799 |
Product Specific Information
- Recommended positive control: Rat liver microsome
- Predicted reactivity: Rhesus Monkey (94%), Chimpanzee (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CYP3A4 encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids. The protein localizes to the endoplasmic reticulum and is induced by glucocorticoids and various pharmacological agents. It metabolizes approximately half of all drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, and erythromycin, as well as certain steroids and carcinogens. This gene is part of a cytochrome P450 cluster on chromosome 7q21.1. Previously identified CYP3A3 is now considered a transcript variant of CYP3A4. Alternative splicing results in multiple isoforms.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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