Thermo Fisher Scientific Phospho-PDPK1 (Ser241) Polyclonal Antibody
Phospho-PDPK1 (Ser241) 특이적 폴리클로날 항체로 Western blot, IHC, ICC/IF에 적합. 인간, 생쥐, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태. 인슐린 신호 및 대사 연구용으로 이상적.
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Thermo Fisher Scientific Phospho-PDPK1 (Ser241) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of serine 241 (A-N-S(p)-F-V) derived from Human PDK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554287 |
Product Specific Information
- Suggested positive control for Western blot: 293 or PC12 cells
- Suggested positive control for IHC: Human breast carcinoma
- Suggested positive control for ICC/IF: HeLa cells
Target Information
PDPK1 (3-Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases and activates conventional PKC and PKC zeta through phosphorylation of threonine residues in the activation loop. It also phosphorylates Protein Kinase B (PKB/Akt) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), leading to glycogen synthase activation and glycogen synthesis stimulation. PDPK1 is a key regulator in insulin-induced glycogen synthesis and PKC activation, making it an important target for metabolic drug research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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