Thermo Fisher Scientific IL10RA Monoclonal Antibody (8A2A5)
IL10RA 단백질을 인식하는 마우스 단클론 항체로, Western blot, ICC/IF, Flow cytometry, ELISA에 사용 가능. 인간 시료 반응성. Protein G로 정제된 액상 형태이며, 4°C 단기 보관 및 -20°C 장기 보관 권장. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:25–1:200 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8A2A5 |
| Immunogen | Purified recombinant fragment of human CD210 (AA: extracellular 22–235) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090825 |
Target Information
The IL10RA gene encodes a receptor for interleukin-10, structurally related to interferon receptors. It mediates the immunosuppressive signal of IL-10, inhibiting the synthesis of proinflammatory cytokines and promoting survival of progenitor myeloid cells via the insulin receptor substrate-2/PI3K/AKT pathway. Activation leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants have been identified, one protein-coding and one non-coding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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