Thermo Fisher Scientific JPH4 Polyclonal Antibody
Thermo Fisher Scientific의 JPH4 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot 및 ELISA에 적합합니다. Rabbit IgG 폴리클로날 항체로, 세포막 및 소포체막 단백질 검출에 사용됩니다. 고순도 친화 크로마토그래피 정제, -20°C 보관.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific JPH4 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA (ELISA)
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 405–605 of human JPH4 (NP_1158282) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.77 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804429 |
Product Specific Information
- Immunogen sequence:
AARMAKLIAQ DLQPMLEAPG RRPRQDSEGS DTEPLDEDSP GVYENGLTPS EGSPELPSSP ASSRQPWRPP ACRSPLPPGG DQGPFSSPKA WPEEWGGAGA QAEELAGYEA EDEAGMQGPG PRDGSPLLGG CSDSSGSLRE EEGEDEEPLP PLRAPAGTEP EPIAMLVLRG SSSRGPDAGC LTEELGEPAA TERPAQPGAA N - Positive Samples: U-87MG, HT-1080, HepG2, 293T, Mouse liver, Rat brain
- Cellular Location: Cell membrane, Endoplasmic reticulum membrane, Peripheral membrane protein, Single-pass type IV membrane protein
Target Information
Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels.
Junctophilins (JPs) are essential components of these complexes, composed of a hydrophobic segment spanning the ER/SR membrane and a cytoplasmic domain with affinity for the PM.
Four tissue-specific subtypes are identified:
- JPH1: Skeletal muscle
- JPH2: All muscle cell types
- JPH3, JPH4: Predominantly expressed in the brain
In the CNS, JPH3 and JPH4 contribute to subsurface cistern formation in neurons. Mice lacking both subtypes exhibit impaired learning, memory, and abnormal nervous functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-87818_JPH4_Q96JJ6-1_Rabbit.svg, PA5-87818_JPH4_Q96JJ6-1_Rabbit_PDP.jpeg)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.