Thermo Fisher Scientific JPH4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA (ELISA)

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  AARMAKLIAQ DLQPMLEAPG RRPRQDSEGS DTEPLDEDSP GVYENGLTPS EGSPELPSSP ASSRQPWRPP ACRSPLPPGG DQGPFSSPKA WPEEWGGAGA QAEELAGYEA EDEAGMQGPG PRDGSPLLGG CSDSSGSLRE EEGEDEEPLP PLRAPAGTEP EPIAMLVLRG SSSRGPDAGC LTEELGEPAA TERPAQPGAA N
• Positive Samples: U-87MG, HT-1080, HepG2, 293T, Mouse liver, Rat brain
• Cellular Location: Cell membrane, Endoplasmic reticulum membrane, Peripheral membrane protein, Single-pass type IV membrane protein

Target Information

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels.
Junctophilins (JPs) are essential components of these complexes, composed of a hydrophobic segment spanning the ER/SR membrane and a cytoplasmic domain with affinity for the PM.
Four tissue-specific subtypes are identified:

• JPH1: Skeletal muscle
• JPH2: All muscle cell types
• JPH3, JPH4: Predominantly expressed in the brain

In the CNS, JPH3 and JPH4 contribute to subsurface cistern formation in neurons. Mice lacking both subtypes exhibit impaired learning, memory, and abnormal nervous functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-87818_JPH4_Q96JJ6-1_Rabbit.svg, PA5-87818_JPH4_Q96JJ6-1_Rabbit_PDP.jpeg)