Thermo Fisher Scientific Phospho-Amyloid Precursor Protein (Thr668) Polyclonal Antibody
인간 APP Thr668 인산화 부위에서 유래한 합성 펩타이드로 제작된 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF 등에 사용 가능. Alzheimer’s disease 연구에 적합하며, 1 mg/mL 농도로 액상 형태로 제공. 연구용으로만 사용.
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- PA5118532
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human APP around the phosphorylation site of Thr668 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903034 |
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating axonal transport of beta-secretase and presenilin 1. APP plays a crucial role in neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with several isoforms due to alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases generates beta amyloid, the main component of senile plaques—one of the major histopathologic features of Alzheimer’s disease. Abnormal regulation and processing of APP are also implicated in Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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