Thermo Fisher Scientific Arginase1 (Hepatocellular Carcinoma Marker) Monoclonal Antibody (ARG1/1126)
Arginase-1 단백질을 표적하는 인간 반응성 마우스 단클론 항체로, 간세포암(HCC) 마커로 활용 가능. Western blot 및 IHC 등 다양한 응용에 적합. 액상 형태, Protein A/G 정제, 4°C 보관.
- 카탈로그번호
- 383-MSM2-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Arginase1 (Hepatocellular Carcinoma Marker) Monoclonal Antibody (ARG1/1126)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 2–4 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ARG1/1126 |
| Immunogen | Recombinant fragment (around aa11–97) of human ARG1 protein (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the final step in the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of byproducts from protein degradation. By degrading arginine, Arginase 1 limits NO synthase substrate availability and downregulates nitric oxide production.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSCs), and neural stem cells. In humans, expression occurs in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a). It may be expressed in myeloid cells infiltrating tumors and is typically found in most hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.