Thermo Fisher Scientific TrxR1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: A431, mouse liver
• Predicted reactivity: Mouse (93%), Rat (92%), Zebrafish (80%), Xenopus laevis (84%), Dog (96%), Pig (93%), Rabbit (96%), Chicken (89%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (93%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress.
The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue required for catalytic activity.
Selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3′ UTR of selenocysteine-containing genes has a common stem-loop structure, the SECIS element, necessary for recognition of UGA as a Sec codon rather than as a stop signal.
Alternative splicing results in several transcript variants encoding the same or different isoforms.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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