Thermo Fisher Scientific C-Myc Polyclonal Antibody, FITC
FITC로 결합된 Rabbit Polyclonal Anti-c-Myc 항체로, WB, ELISA, IP 등 다양한 응용에 적합. 인간 및 고양이 등 여러 종에 반응. 고순도 친화 크로마토그래피 정제. 암 연구 및 세포 증식 관련 단백질 분석에 유용.
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Thermo Fisher Scientific C-Myc Polyclonal Antibody, FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Cat, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 200–250 on human c-Myc protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK regulates its function in cell proliferation.
c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated expression of c-Myc can induce apoptosis and is associated with various human cancers, including lung, breast, and colon carcinomas, as well as Burkitt’s lymphoma and other B-cell lymphoproliferative disorders.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc tags and are widely used in research related to oncogenesis and cell growth regulation.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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