Thermo Fisher Scientific GNA11 Polyclonal Antibody
GNA11 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 실험에 적합합니다. Human, Mouse, Pig, Rat 시료에서 반응하며, 고순도 Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적으로 저장 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GNA11 (Accession P29992), corresponding to amino acid residues T122–Y172 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852050 |
Product Specific Information
Antibody detects endogenous levels of total GNA11.
Target Information
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β, and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines, and sensory stimuli.
Over 20 known Gα subunits have been classified into four families — Gα(s), Gα(i/o), Gα(q), and Gα(12) — based on structural and functional similarities.
Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, as substitution of phenylalanine for Tyr356 disrupts receptor interaction and abolishes ligand-induced IP3 formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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