Thermo Fisher Scientific Osteopontin (OSP)/Secreted Phosphoprotein 1 (SPP1) Monoclonal Antibody (OSP/4589)
Osteopontin(SPP1) 단백질을 인식하는 Rat IgG1 단클론 항체로, WB, IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. 뼈, 혈장 등에서 발현되는 OPN 검출에 적합하며, 세포 부착·면역조절 연구에 활용. 4°C 보관, 200 µg/mL 농도.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Avian, Dog, Human, Mink, Mouse, Rabbit, Rat |
| Host/Isotype | Rat / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OSP/4589 |
| Immunogen | Recombinant full-length rat Spp1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Bone; found in plasma.
- Cellular Localization: Secreted.
- Specificity Comments:
Osteopontin is a bone matrix protein and cytokine secreted by activated T cells. It is an extracellular matrix cell adhesion phosphoglycoprotein deposited into unmineralized matrix prior to calcification, localizing at tissue interfaces such as cement lines and between collagen fibrils.
While primarily produced by osteoblasts, it is also synthesized by brain and kidney cells. Osteopontin variants differ in molecular weight due to post-translational modifications.
Functions include acting as a substrate for transglutaminase and involvement in cell adhesion, chemoattraction, and immunomodulation.
Target Information
Osteopontin is an RGD-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is involved in bone mineralization, cell adhesion, migration, chronic inflammation, and transformation.
Proteolytic cleavage by thrombin and matrix metalloproteinases near the RGD sequence modulates OPN’s function and integrin binding.
Thrombin-cleaved fragments are overexpressed in malignant glial tumors, providing a survival niche and novel substrates for plasmin and cathepsin D.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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