Thermo Fisher Scientific Human AIPL1 Synthetic Peptide
Human AIPL1 단백질의 17개 아미노산 서열 기반 합성 펩타이드로, 항체 차단 실험에 사용 가능. 인간 특이적 반응성을 가지며, PBS 버퍼 내 액상 형태로 제공. 연구용으로만 사용 가능하며 진단용 불가.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human Aipl1.
PEP-0743 can be used as a blocking peptide with polyclonal antibody PA5-20623.
Target Information
Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder caused by abnormal development of photoreceptors.
Aipl1 is a tetratricopeptide repeat protein highly homologous to ARA9, which is involved in HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor.
Aipl1 functions as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70, and associates with the cell cycle regulator NUB1.
It cooperates with Hsp70 but not Hsp90 to suppress NUB1 inclusion formation, essential for normal photoreceptor maturation.
Mutations disrupting these interactions lead to LCA.
At least three isoforms of Aipl1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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