Thermo Fisher Scientific NOX4 Polyclonal Antibody
Thermo Fisher Scientific의 NOX4 Polyclonal Antibody는 Human, Mouse, Rat에서 반응하며, Western blot, IHC, ICC, ELISA, IP 등 다양한 어플리케이션에 적합합니다. Rabbit에서 유래한 IgG 폴리클로날 항체로, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 8 publications |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | – |
| Immunocytochemistry (ICC/IF) | – | View 2 publications |
| ELISA | Assay-Dependent | – |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 14 amino acid peptide near the amino terminus of human NOX4 (within amino acids 70–120 of NOX4) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718670 |
Target Information
Oxygen sensing is essential for homeostasis in aerobic organisms. A phagocyte-type oxidase, similar to that responsible for reactive oxygen species (ROS) production in neutrophils, is proposed to function in the kidney as an oxygen sensor regulating erythropoietin synthesis.
NOX4 acts as a redox messenger in intracellular signaling pathways contributing to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells.
Data suggest that NOX4 links the insulin receptor to ROS generation, enhancing insulin signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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