Thermo Fisher Scientific OCRL Polyclonal Antibody
Thermo Fisher Scientific의 OCRL Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 Western blot에 사용 가능한 고순도 항체입니다. 합성 펩타이드(aa 180–230)를 면역원으로 사용하여 제작되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 180–230 of Human OCRL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2719098 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
The inositol polyphosphate 5-phosphatases selectively remove phosphate from the 5-position of various phosphatidylinositols, generating second messengers in response to extracellular signals.
OCRL1 is a type II 5-phosphatase mutated in the oculocerebrorenal syndrome of Lowe (OCRL), a rare X-linked disorder characterized by congenital cataracts, mental retardation, muscular hypotonia, and renal tubular dysfunction.
OCRL1 has high affinity for phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate, and inositol 1,3,4,5-tetrakisphosphate as substrates. It is localized to the Golgi complex and is thought to be part of the trans-Golgi network (TGN), suggesting a role in protein sorting and trafficking within the cell.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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