Thermo Fisher Scientific GABBR1 Monoclonal Antibody (2D7)
GABBR1 단백질을 인식하는 Mouse IgG2a 단일클론 항체로 Western blot, ICC/IF, ELISA에 적합. 인간 시료에 반응하며 비결합형 액상 형태. PBS 버퍼에 보존제 없이 -20°C에서 보관. 신경전달 억제 조절 연구에 유용.
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Thermo Fisher Scientific GABBR1 Monoclonal Antibody (2D7)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D7 |
| Immunogen | GABBR1 (AAH50532, 52 a.a. approximately 151 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AVYIGALFPM SGGWPGGQAC QPAVEMALED VNSRRDILPD YELKLIHHDS KCDPGQATKY LYELLYNDPI KIILMPGCSS VSTLVAEAAR MWNLIVLSYG
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that:
- Inhibit adenylyl cyclase activity
- Stimulate phospholipase A2
- Activate potassium channels
- Inactivate voltage-dependent calcium channels
- Modulate inositol phospholipids hydrolysis
Plays a critical role in fine-tuning inhibitory synaptic transmission.
Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating inwardly rectifying potassium (Kir) conductance.
Involved in synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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