Thermo Fisher Scientific IFN alpha Polyclonal Antibody

Thermo Fisher Scientific IFN alpha Polyclonal Antibody

Applications

• Neutralization (Neu)

Tested Dilution

• Assay-dependent

Publications

• [References not provided]

Product Specifications

Product Specific Information

• Specificity: Neutralizes mouse interferon alpha.
• Activity: Interferon was titrated using the cytopathic effect inhibition assay with L929 cells, where 5 units/mL of interferon produced a 50% endpoint. One neutralization unit equals the amount of serum required to neutralize one unit of mouse IFN alpha to a 50% endpoint.
• Storage: Store at -20°C for short-term use (less than 6 months). For long-term storage, aliquot and store at -70°C or below. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution should be performed in buffers containing protein (e.g., 0.1% BSA).
• Packaging: Packaged by and distributed for PBL Assay Science.

Target Information

IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins found in vertebrates. Interaction with its receptor activates signaling pathways involved in innate immune response against viral infection.
In humans, the IFN alpha gene is located on chromosome 9. Type I interferons include 14 alpha isoforms and single beta, omega, epsilon, and kappa isoforms. Homologous molecules exist in many species including rodents, birds, reptiles, and fish.
Produced primarily by plasmacytoid dendritic cells, IFN alpha plays a key role in antiviral defense and modulation of adaptive immunity. Dysfunction of IFN alpha is associated with diseases such as Hepatitis C and Hepatitis B.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.