Thermo Fisher Scientific PSMA8 Monoclonal Antibody (21D11)
PSMA8 단클론 항체(21D11)는 인간 및 마우스 시료에서 단백질 검출에 사용됩니다. Western blot, ELISA, IP 등 다양한 응용에 적합합니다. 비결합형(mouse IgG2a) 항체로, -20°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–5 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| ELISA | 1.0–5 µg/mL | – |
| Immunoprecipitation (IP) | 5–10 µg | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Published species | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 21D11 |
| Immunogen | Cellular proteasome fraction containing multiple α subunits, prepared from bovine cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2533064 |
Target Information
PSMA8 is a component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby actively participating in histone exchange during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. PSMA8 is required for 20S core proteasome assembly and is essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I, facilitating the progression of meiosis I during spermatogenesis. It localizes to the synaptonemal complex, a zipper-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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