Thermo Fisher Scientific IkB epsilon Polyclonal Antibody
IkB epsilon 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 사용 가능. 비접합형 액상 형태이며 농도는 1 mg/mL. 인산화되지 않은 Ser22 부근 합성 펩타이드로 면역화됨. 연구용으로만 사용.
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Thermo Fisher Scientific IkB epsilon Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic non-phosphopeptide derived from human IkB-epsilon around phosphorylation site of Ser22 (I-E-SP-L-R) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554674 |
Target Information
NFKB1 or NFKB2 binds to REL, RELA, or RELB to form the NFKB complex. This complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which trap NF-kappa-B in the cytoplasm. Phosphorylation of serine residues on I-kappa-B by kinases (IKBKA or IKBKB) triggers ubiquitination and degradation, allowing NF-kappa-B activation. Activated NF-kappa-B translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5'-GGGRNNYYCC-3' or 5'-HGGARNYYCC-3'. Activation of certain genes may require interaction with transcription factors such as STAT, AP1, and NFAT.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-38071_IkB_epsilon_O00221-1_Rabbit.svg, PA5-38071_IkB_epsilon_O00221-1_Rabbit_PDP.jpeg)
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