Thermo Fisher Scientific Desmoglein 3 Monoclonal Antibody (5G11)
Desmoglein 3 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC, Flow Cytometry 등 다양한 응용에 적합합니다. 인간 및 마우스 반응성이 있으며, Protein G 정제, 액상 형태로 제공됩니다. 연구용으로 피부 및 점막 관련 세포 접착 연구에 활용됩니다.
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Thermo Fisher Scientific Desmoglein 3 Monoclonal Antibody (5G11)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 4 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | View 3 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | View 4 publications |
| Flow Cytometry (Flow) | 1 µg per million cells | View 1 publication |
| Immunoprecipitation (IP) | 1:10–1:500 | View 2 publications |
| Dot blot (DB) | Assay-Dependent | – |
| Miscellaneous PubMed (Misc) | – | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5G11 |
| Immunogen | Human Desmoglein 3 recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152790 |
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a desmosomal cadherin that plays a critical role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium such as skin, oral mucosa, and esophagus. Desmoglein 3 is the autoantigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies leads to loss of cell-cell adhesion, clinically manifesting as blisters on the skin and mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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