Thermo Fisher Scientific HAP 1A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: HAP1A.

Target Information

Huntington's disease (HD) is a neurodegenerative disorder characterized by loss of striatal neurons, caused by an expansion of a polyglutamine tract in the huntingtin protein. HAP1 was initially identified through two-hybrid library screening, showing binding correlation with huntingtin expansion. HAP1 interacts with cytoskeletal proteins such as dynactin and pericentriolar autoantigen protein 1, suggesting a role in vesicular trafficking or organelle transport. HAP1 is also involved in huntingtin-enhanced BDNF transport along microtubules, where attenuation leads to loss of neurotrophic support and neuronal toxicity, potentially contributing to disease pathogenesis. Several alternatively spliced isoforms have been described for HAP1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.