Thermo Fisher Scientific HAP 1A Polyclonal Antibody
Thermo Fisher Scientific의 HAP1A 폴리클로날 항체로 마우스 시료에 반응. Western blot 및 IHC에 적합하며, HAP1 단백질 연구용으로 사용. 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적 유지 가능.
- 카탈로그번호
- OSH00042W-100UL
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region of 580–598 of mouse HAP1A conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: HAP1A.
Target Information
Huntington's disease (HD) is a neurodegenerative disorder characterized by loss of striatal neurons, caused by an expansion of a polyglutamine tract in the huntingtin protein. HAP1 was initially identified through two-hybrid library screening, showing binding correlation with huntingtin expansion. HAP1 interacts with cytoskeletal proteins such as dynactin and pericentriolar autoantigen protein 1, suggesting a role in vesicular trafficking or organelle transport. HAP1 is also involved in huntingtin-enhanced BDNF transport along microtubules, where attenuation leads to loss of neurotrophic support and neuronal toxicity, potentially contributing to disease pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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