Thermo Fisher Scientific GAS2L1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: A431, HeLa, A375, mouse brain
• Predicted reactivity: Mouse (86%), Rat (86%), Pig (91%), Bovine (89%)
• Store product as a concentrated solution
• Centrifuge briefly prior to opening the vial

Target Information

The Gas2 protein is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by caspase-3 or caspase-7 at Asparagine 278 during apoptosis. The cleaved form of Gas2 induces re-arrangement of the actin cytoskeleton and causes morphological changes in cells. Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with actin fibers at the cell border and along stress fibers in growth-arrested fibroblasts. It is mainly membrane-associated, but upon hyperphosphorylation, accumulates at membrane ruffles, indicating involvement in membrane dynamics. Gar22 (Gas2-related protein on chromosome 22), also known as growth arrest-specific protein 2-like 1 (Gas2-like1), belongs to the Gas2 family and contains one CH (calponin homology) domain, suggesting a role in cross-linking microtubules and microfilaments.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.