Thermo Fisher Scientific CDKN1A Monoclonal Antibody (OTI2D3), TrueMAB
CDKN1A(p21) 단백질을 인식하는 단클론 항체로, Western blot에 적합합니다. 인간 시료 반응성이 있으며, Mouse IgG1 형식입니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관이 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 2–164 of human CDKN1A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. It plays a key role in the cellular response to genotoxic stress and is a major transcriptional target of p53. Nuclear p21 binds and inhibits Cdk1 and Cdk2, blocking the transition from G1 to S phase or G2 to mitosis after DNA damage, allowing DNA repair. In the cytoplasm, p21 exhibits anti-apoptotic activity by inhibiting caspase 3, ASK1, and JNK. p21 has dual roles in cancer, acting both as a tumor suppressor and, in some contexts, as an oncogene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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