Thermo Fisher Scientific PHLDA1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MLESSGCKAL KEGVLEKRSD GLLQLWKKKC CILTEEGLLL IPPKQLQHQQ QQQQQQQQQQ QQPGQGPAEP SQPSGPAVAS LEPPVKLKEL HFSNMKTVDC VERKGKYMYF TVVMAEGKEI DFRCPQDQGW NAEITLQMVQ YKNRQAILAV KSTRQKQQHL VQQQPPSQPQ PQPQLQPQPQ PQPQPQPQPQ SQPQPQPKPQ PQQLHPYPHP HPHPHPHSHP HSHPHPHPHP HPHQIPHPHP QPHSQPHGHR LLRSTSNSA

Target Information

Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity:

• A perforin-based process
• A FAS-based mechanism involving the transducing molecule FAS (APO-1) and its ligand (FAS-L)

The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors including CD40, nerve growth factor receptors, and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines and at high levels in T cells following TCR crosslinking. A previously undescribed protein, TDAG51, restores activation-induced apoptosis in cells that have lost Fas display in response to activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.