Thermo Fisher Scientific Interleukin-15 (IL-15) Monoclonal Antibody (IL15/4355)
인간 IL-15를 인식하는 단일클론 항체로, T세포 및 NK세포 활성 연구에 적합합니다. IHC(P), IHC(PFA), Peptide Array 등 다양한 응용 가능. 고순도 Protein A/G 정제, -20°C 보관, 연구용 전용 제품.
- 카탈로그번호
- 3600-MSM5-P1ABX
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Interleukin-15 (IL-15) Monoclonal Antibody (IL15/4355)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL15/4355 |
| Immunogen | Recombinant fragment of human IL15 (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IL-15 (Interleukin 15) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both bind common hematopoietin receptor subunits and may compete for the same receptor, negatively regulating each other’s activity. The number of CD8+ memory cells is controlled by a balance between IL-15 and IL-2.
IL-15 induces activation of JAK kinases and phosphorylation of STAT3, STAT5, and STAT6. In mouse models, IL-15 may increase expression of apoptosis inhibitor Bcl-xL through STAT6 activation, preventing apoptosis.
IL-15 plays a critical role in growth and differentiation of T and B lymphocytes, NK cells, macrophages, and monocytes, and in activation of key intracellular signaling molecules. It is essential for immune responses, allograft rejection, and autoimmune disease pathogenesis.
IL-15 is a pro-inflammatory cytokine implicated in disorders such as rheumatoid arthritis, psoriasis, and pulmonary inflammation. Neutralization of IL-15 shows therapeutic potential in models of psoriasis and diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.