Thermo Fisher Scientific Interleukin-15 (IL-15) Monoclonal Antibody (IL15/4355)
인간 IL-15를 인식하는 단일클론 항체로, T세포 및 NK세포 활성 연구에 적합합니다. IHC(P), IHC(PFA), Peptide Array 등 다양한 응용 가능. 고순도 Protein A/G 정제, -20°C 보관, 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL15/4355 |
| Immunogen | Recombinant fragment of human IL15 (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IL-15 (Interleukin 15) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both bind common hematopoietin receptor subunits and may compete for the same receptor, negatively regulating each other’s activity. The number of CD8+ memory cells is controlled by a balance between IL-15 and IL-2.
IL-15 induces activation of JAK kinases and phosphorylation of STAT3, STAT5, and STAT6. In mouse models, IL-15 may increase expression of apoptosis inhibitor Bcl-xL through STAT6 activation, preventing apoptosis.
IL-15 plays a critical role in growth and differentiation of T and B lymphocytes, NK cells, macrophages, and monocytes, and in activation of key intracellular signaling molecules. It is essential for immune responses, allograft rejection, and autoimmune disease pathogenesis.
IL-15 is a pro-inflammatory cytokine implicated in disorders such as rheumatoid arthritis, psoriasis, and pulmonary inflammation. Neutralization of IL-15 shows therapeutic potential in models of psoriasis and diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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