Thermo Fisher Scientific TCR V alpha 12.1 Monoclonal Antibody (6D6.6)
Thermo Fisher Scientific의 TCR V alpha 12.1 Monoclonal Antibody (6D6.6)은 인간 및 랫트 반응성을 가진 단클론 항체로, 다양한 면역학적 분석(WB, IHC, Flow Cytometry 등)에 사용됩니다. Protein G로 정제된 액상 형태이며, 연구용으로 TCR 관련 면역 반응 연구에 적합합니다.
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카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | 1–2 µg/test | View 5 publications |
| Immunoprecipitation (IP) | Assay-dependent | - |
| T-Cell Activation (TCA) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D6.6 |
| Immunogen | Human TCR V alpha 12.1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.5% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_223507 |
Additional Formats
Target Information
T cell receptors (TCRs) play a crucial role in distinguishing foreign peptides from self-peptides presented by MHC class II molecules, which is essential for adaptive immune responses. Recognition of self-peptides by TCRs has been linked to autoimmune diseases, while mutant self-peptides are associated with tumors. Engagement of TCRs by bacterial superantigens can lead to toxic shock syndrome. Autoantibodies to V beta segments of TCRs have been found in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), potentially serving as a compensatory immune mechanism.
Most human T cells express TCR alpha-beta and either CD4 or CD8 molecules (single positive, SP). A smaller subset lacks both (double negative, DN), which may increase in certain autoimmune or immunodeficiency disorders. Gamma-delta T cells, mainly found in epithelial tissues, exhibit less TCR diversity and distinct antigen recognition, with subsets showing antitumor and immunoregulatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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