Thermo Fisher Scientific Cardiac Troponin I Monoclonal Antibody (267)
인체 심근 트로포닌 I를 인식하는 마우스 단클론 항체로, Western blot, IHC, IP, AP 등 다양한 응용에 사용 가능. 단백질 A로 정제된 액상 항체이며, 4°C에서 보관. 심근 손상 연구용으로 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (IHC) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Affinity Purification (AP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 267 |
| Immunogen | Free human cardiac troponin I, native human cardiac troponin complex, or human cardiac troponin I peptides |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5.4 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_561831 |
Product Specific Information
MA1-20878 detects Cardiac Troponin I in human samples.
Target Information
Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that forms a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit binds to tropomyosin, forming a troponin-tropomyosin complex anchored by the binding of TnI to actin within muscle thin filaments.
When calcium binds to specific sites on TnC, it induces a structural change that releases the inhibitory region of TnI from actin, enabling myosin attachment and muscle contraction.
Measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage and helps differentiate between angina and myocardial infarction in patients with chest pain.
Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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