Thermo Fisher Scientific NAT1 Monoclonal Antibody (OTI4E9), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates involved in the detoxification of various drugs.
Certain alleles with high N-acetyltransferase activity have been linked to colon and urinary bladder cancers, as NATs can bioactivate known carcinogens.
Both NAT-1 and NAT-2 are cytoplasmic proteins that play a role in detoxifying arylamine and hydrazine drugs.
N-acetylation polymorphism is determined by NAT activity levels in liver tissue and is associated with the action and toxicity of amine-containing drugs.
Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 corresponds to rodent NAT-1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.