Thermo Fisher Scientific Nur77 Polyclonal Antibody
Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용 가능. Human, Mouse, Rat 반응성. Rabbit Polyclonal IgG 항체로 1 mg/mL 농도, Protein A 정제. NR4A1(Nur77) 타깃으로 세포 사멸 및 신호전달 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Nur77/GFRP, amino acids 351–450 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NR4A1 (Nur77) is a member of the steroid-thyroid hormone-retinoid receptor superfamily. It is expressed in the brain, adrenal gland, thyroid, liver, testis, ovary, thymus, muscle, lung, and prostate. Expression is induced by various stress stimuli and growth factors.
The encoded protein functions as a nuclear transcription factor involved in apoptotic signaling in thymocytes and tumor cells, and also participates in hypothalamic-pituitary axis signaling. Translocation of NR4A1 from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two isoforms have been identified. Variant 3 (TRC beta) differs from variant 1, producing a shorter C-terminus isoform. RXR has been identified as a partner for NR4A1.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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