Thermo Fisher Scientific IDO1 Monoclonal Antibody (UMAB126), UltraMAB
IDO1 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western blot, IHC, ICC/IF, ChIP 등 다양한 연구용 분석에 적합. HEK293T에서 생산된 full-length human recombinant protein을 면역원으로 사용. 고순도 친화 크로마토그래피 정제 및 안정적 PBS/BSA/glycerol buffer 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
| ChIP assay (ChIP) | Assay-dependent |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB126 |
| Immunogen | Full-length human recombinant protein of human IDO1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IDO1 (Indoleamine 2,3-dioxygenase 1) is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of regulatory molecules such as tryptophan, serotonin, and melatonin. This process leads to the formation of biologically active metabolites known as kynurenines.
IDO1 is broadly expressed in human tissues, macrophages, and dendritic cells (DCs). Inflammatory stimuli, particularly interferons (IFNs), induce IDO1 expression, contributing to antimicrobial defense mechanisms.
Tryptophan degradation by IDO1 inhibits the growth of viruses, bacteria, and parasites. Moreover, IDO1 plays a crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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