Thermo Fisher Scientific RAP80 Polyclonal Antibody
RAP80 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 ICC/IF에 적합하며, 인간·마우스·랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체로 DNA 손상 반응 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human RAP80 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720908 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% as determined by SDS-PAGE.
Target Information
RAP80 is a zinc-finger containing nuclear protein highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). It is recruited by CCDC98 to BRCA1, enabling BRCA1 foci formation in response to DNA damage. RAP80 and CCDC98 are essential for DNA damage resistance, G2-M checkpoint control, and repair mechanisms. Depletion of either protein increases sensitivity to ionizing radiation, though less than BRCA1 depletion, suggesting partial involvement in BRCA1-mediated DNA damage response. At least four isoforms of RAP80 exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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